Biomechanical Comparison of Two-Point and Three-Point Fixation for Treating SandersⅢ Calcaneal Fracture / 医用生物力学

Objective To analyze the biomechanical feasibility of two-point fixation by distal radius plate for the treatment of SandersⅢ calcaneal fractures. Methods The three-dimensional (3D) finite element musculoskeletal foot model was established based on CT and MRI images, which comprised bones, muscles, plantar fascia, ligaments and soft tissues. After validation, the SandersⅢ calcaneal fracture models fixed by distal radial plate (two-point fixation) and calcaneal plate (three-point fixation) were established, so as to compare the biomechanical characteristics of two calcaneal models. Results The maximum stress of the two-point fixation and three-point fixation model was 324.70 and 407.90 MPa, respectively. The maximum displacements of the two models were 2.498 and 2.541 mm, respectively. There was no significant difference in the posterior articular surface displacement between the two models. In both models, the Bohler’s angle and Gissane’s angle were within the normal range. Conclusions The two-point fixation by distal radial plate can satisfy the biomechanical stability of calcaneal fracture treatment. Compared with traditional steel plate, the two-point fixation shows the advantage of smaller surgical trauma, more uniform overall stress distribution, early weight-bearing rehabilitation after surgery, which is a novel treatment recommended for treating calcaneal fractures.

Second-line injectable drugs resistance-associated mutation among multi-drug resistant tuberculosis strains in Ningbo, China / 中国人兽共患病学报

We identified the Beijing family strains of multiple drug-resistant tuberculosis and find out the distribution of second-line injectable drugs resistance-associated nucleotide alteration among the MDR strains in Ningbo.The 106 MDR isolates were selected from the first drug resistant survey in Ningbo during 2014 and 2016.The conventional drug susceptibility testing was used to detect the drug-resistant profiles against 3 second-line injectable drugs (kanamycin,amikacin,capreomycin).The RD105 deletion-targeted multiplex PCR method was used to distinguish the genotype among 106 MDR strains.The gene mutations of second-line injectable drugs resistance-associated among MDR-TB strains were detected by direct DNA sequencing.Results showed that out of the 106 MDR isolates,83(78.3％,83/106) belonged to Beijing genotype,while the other 23(21.7％,23/106) were non-Beijing genotype.There were 10 strains with second-line injectable drugs resistance in 83 Beijing genotype MDR strains and there were no strains with second-line injectable drugs resistance in 23 non-Beijing genotype MDR strains.The Beijing MDR strains had significantly higher proportions of second-line injectable drugs resistance than non-Beijing strains.There were 4 with mutations in 10 MDR-TB with second-line injectable drugs resistance and there were 24 with mutations in 96 MDR-TB without second-line injectable drugs resistance (x2=1.048,P＞0.05).Beijing genotype MDR strains revealed a significant association with second-line injectable drugs resistance.The mechanism of second-line injectable drugs resistance in MDR-TB is mainly in no connection with the mutation of the genes.

Retraction notice to: Effect of transplantation of BMMSCs on pathological change of gastric precancerous lesions of rats Asian Pac J Trop Med 8(12) (2015) 1060–1063 (S1995764515001911) (10.1016/j.apjtm.2015.11.006))

This article has been retracted at the request of first author, corresponding author and the editor-in-chief of the journal. The authors have plagiarized some parts of the figures and results which are similar to Yuan Gong's doctoral dissertation ‘Experimental study on the effects of bone marrow mesenchymal stem cells in the model of gastric precancerous lesion’ published in the China National Knowledge Infrastructure (http://www.cnki.net). One of the conditions of submission of a paper for publication is that authors declare explicitly that their work is original and has not appeared in a publication elsewhere. Re-use of any data should be appropriately cited. As such this article represents an abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

RETRACTED: Effect of transplantation of BMMSCs on pathological change of gastric precancerous lesions of rats

OBJECTIVE@#To build the rat model of gastric precancerous lesions and discuss the effect of transplantation of mesenchymal stem cells (BMMSCs) on the pathological change.@*METHODS@#The rat model of gastric precancerous lesions was built using N-methyl-N'-nitro-N'-nitrosoguanidine. After the intravenous transplantation of BMMSCs, the migration and colonization location was then observed, as well as its effect on the related factors of gastric precancerous lesions, including VEGF, IL-10 and IFN-γ.@*RESULTS@#BMMSCs were mainly colonized in the gastric body and gastric antrum, which could be differentiated into the epithelial and interstitial cells. The expression of VEGF in the transplantation group and non-transplantation group was significantly higher than that in the control group (P < 0.05); while the expression of VEGF in the transplantation group was significantly higher than that in the non-transplantation group (t = 3.88, P < 0.001). The expression of serum IL-10 and IFN-γ in the transplantation group and non-transplantation group was significantly higher than that in the control group (P < 0.05), while the expression of IL-10 and IFN-γ in the transplantation group was significantly lower than that in the non-transplantation group (t = 3.03, P = 0.004; t = 3.80, P < 0.001).@*CONCLUSIONS@#BMMSCs can be directionally differentiated into the epithelial and interstitial cells and can also regulate the related growth factors and inflammatory factors to reduce the injury of inflammation, relieve or reverse the process of gastric precancerous lesions.

Effect of transplantation of BMMSCs on pathological change of gastric precancerous lesions of rats

Objective: To build the rat model of gastric precancerous lesions and discuss the effect of transplantation of mesenchymal stem cells (BMMSCs) on the pathological change. Methods: The rat model of gastric precancerous lesions was built using N-methyl-N'-nitro-N'-nitrosoguanidine. After the intravenous transplantation of BMMSCs, the migration and colonization location was then observed, as well as its effect on the related factors of gastric precancerous lesions, including VEGF, IL-10 and IFN-γ Results: BMMSCs were mainly colonized in the gastric body and gastric antrum, which could be differentiated into the epithelial and interstitial cells. The expression of VEGF in the transplantation group and non-transplantation group was significantly higher than that in the control group (P < 0.05); while the expression of VEGF in the transplantation group was significantly higher than that in the non-transplantation group (t = 3.88, P < 0.001). The expression of serum IL-10 and IFN-γ in the transplantation group and non-transplantation group was significantly higher than that in the control group (P < 0.05), while the expression of IL-10 and IFN-γ in the transplantation group was significantly lower than that in the non-transplantation group (t = 3.03, P = 0.004; t = 3.80, P < 0.001). Conclusions: BMMSCs can be directionally differentiated into the epithelial and interstitial cells and can also regulate the related growth factors and inflammatory factors to reduce the injury of inflammation, relieve or reverse the process of gastric precancerous lesions.